Te Wewete I Te Pumanawa O Te Paura Kaempferol Mo Koe Kia Ora

Kaempferol he pūhui waro me te tātai matū C15H10O6. He pūhui flavonoid, he paura tioata kōwhai. He paku wairewa ki te wai me te wairewa i roto i te waiwaro wera, te etera, te wairewa kawakore ranei. Ko te nuinga he antibacterial, anti-inflammatory, mare mare me te expectorant. pānga.

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Ko te kaempferol he puhui flavonoid, e mohiotia ana ko te kaempferol-3, te kaempferol, te kaempferol, me te caempferol, e kitea nuitia ana i roto i nga tipu taiao penei i nga hua, huawhenua, me nga rongoa rongoa Hainamana. Nga Painga: Ko te Kaempferol he antioxidant, he anti-inflammatory, he mate pukupuku, he aukati me te rongoa i te mate huka, te atherosclerosis me te osteoporosis, te tiaki i nga nerves, te ate me te myocardium, te aukati i nga kinases pūmua me etahi atu mahi kai me te tiaki hauora. He tino whanui te maakete a Kaempferol hei kai hauora me te rongoa.

takanga

1) Waiwai ki te whakarite hydroxyacetophenone takawaenga 1.1) Hoatu 30g o dihydromyricetin ki te ihirangi o te neke atu i te 98% ki te reactor, ka tāpiri 400g o te wairewa konutai waihā me te hautanga papatipu o 15%, whakaohokia me te uru rite, hiki te pāmahana me te reflux , ka haere tonu te tauhohenga Hydrolysis; ka aroturukihia e te chromatography wai mahi nui, ko te mutunga o te mana tauhohenga ka kore e piki ake te takawaenga hydroxyacetophenone. I muri i te 2 haora, ka mutu te tauhohenga. Whakamaohia te pāmahana ki te 30°C, āta tāpirihia te wairewa waikawa pūmāota 50% ki roto i te wairewa tauhohenga, whakatikahia te pH kia 6.2 pea, whakaohokia mo te 2 haora, kia tu mo te 1 haora, ka tātari kia puta he totoka kowhai kowhai marama. 1.2) Tāpirihia te 150g o te 95% te waihā ki te mārō kōwhai kōwhai marama i whiwhi i te taahiraa 1.1), te whakamahana me te reflux mo te 1 haora, ka tātari i te wa e wera ana kia puta he totoka, katahi ka tapirihia te 90g o te 95% te waihā ki te totoka, te wera me te reflux mo te 1 haora, ka whakaheke ki te Tukua kia tu mo te 2 haora i te pāmahana rūma, ka tātari ka whakamaroke kia whiwhi 17.8 g o te totoka kowhai marama, ara te hydroxyacetophenone takawaenga (2-hydroxy-1-(2,4,6-trihydroxyphenyl )acetyl).

2) Katinga mowhiti catalytic ki te whakarite dihydrokaempferol masivesivá 2.1) Hoatu 17.8g o te takawaenga hydroxyacetophenone whiwhi i te tauhohenga i roto i te taahiraa 1.2) ki te pounamu tauhohenga, tāpiri 92g o DMF, ka whakaoho kia rewa rawa te takawaenga hydroxyacetophenone. 2.2) Tāpirihia te 3.55g o te proline ki te otinga i te taahiraa 2.1), whakanekehia te pāmahana ki te 65°C me te pupuri tonu i te pāmahana. Whakarewahia te 13.9g o te p-hydroxybenzaldehyde ki roto i te 20g o te DMF ka ata taapiri atu ki roto i te pounamu hohenga, ka mutu te maturuturunga iho mo te 2 haora. I muri i te otinga o te whakamahu, ka piki te pāmahana ki te 70°C ka noho mahana, ka mahia he tauhohenga kati-koropiko catalytic. Ka aro turukihia e te chromatography wai mahi nui, ko te mutunga o te mana tauhohenga ka kore e piki ake te takawaenga dihydrokaempferol. Ka mutu te tauhohenga i muri tata ki te 7 haora. 2.3) Whakahekea te wairewa i puta mai i te taahiraa 2.2) ki te pāmahana rūma, tāpirihia te 350g o te 5% wairewa waikawa ahetiki hukapapa, whakaohokia mo te 2 haora, ka ata tohe i te totoka. Tātarihia, horoia te keke tātari ki te wai tae noa ki te kūpapa ka maroke kia whiwhi 27.6g o te dihydrokaempferol masivesivá. 3) Whakapaia te kaempferol mā te hāora me te whakakapi i te taahiraa 2.

3) 27.6g o te dihydrokaempferol masivesivá kua whiwhi ki roto i te pounamu tauhohenga, 275ml o te 65% te waihano i tapirihia, i oho riterite, katahi ka tapirihia te 6g o te konupora konupora warowaiha, ka whakauruhia te hāora, katahi ka hiki te pāmahana ki te reflux ki te mahi. he tauhohenga waiora, me te mahi teitei o te chromatography wai. Aroturuki, a ko te mutunga o te mana tauhohenga ka kore e piki ake te kaempferol. Ka mutu te tauhohenga i muri tata ki te 8 haora. Whakaitihia ki te pāmahana rūma ka waiho mo te po, tātari kia whiwhi totoka kōwhai, tāpirihia te 200g wai, reflux mo te 2 haora, tātari, horoia te keke tātari ki te wai ka whakamaroke kia 22.3 karamu o te kaempferol, te ihirangi 98% (HPLC).

whakamahi:

Anti-mate pukupuku

I te mea ko te flavonoids tino noa, ko te kai mo te wa roa o te kaempferol ka whakaiti i te tupono o te mate pukupuku. E ai ki nga rangahau ka taea e te kai nui o te kaempferol te whakaheke i te hokinga mai o te adenoma colorectal i te mutunga o te wa, a, ka whakatauritea ki etahi atu flavonoids kai o ia ra, ko te kai nui o te kaempferol ka tino whakaitihia te mate o te mate pukupuku pancreatic. Ko nga rangahau hou e whakaatu ana ka taea ano e te kaempferol te aukati i te tauwehe tupu hepatocyte (HGF) me tona kinase protein tyrosine receptor, e pa ana ki te tipu me te metastasis o te medulloblastoma i roto i nga tamariki. Na reira, ka taea te whakamahi kaempferol kai hei aukati me te aukati i te medulloblastoma. Mahia tenei mate.

Anti-infection and anti-inflammatory

Ko nga rangahau e whakaatu ana he pai te mahi antibacterial a kaempferol, he pai hoki ki te aukati i te methicillin-resistant Staphylococcus aureus (MRSA). Ko te tikanga kōpae K-Br e whakaatu ana ko te kukū o te 50 mg/papa ka taea e te rohe aukati o MRSA te eke ki te 8.5 mm, he pai hoki te mahi antibacterial ki a Vibrio cholerae me Enterococcus faecalis. I runga i nga paanga antiviral, ka taea e te kaempferol te whakaatu i te aukati i te kukū-whakaaro ki nga kukū kore-cytotoxic.

I roto i nga tikanga o te anti-inflammatory, ko te kaempferol te nuinga o te whakatutuki i nga paanga anti-inflammatory ma te aukati i te whakapuakitanga o nga mea inflammatory.

Te aukati me te maimoatanga o te mate huka

Ko te Atherosclerosis (AS) he mate mumura roa o te pakitara oko toto. Kua whakaatuhia e nga rangahau e kore e taea e te kaempferol anake te aukati i te konupora katote-whakaheke i te waiora o te iti-kiato lipoprotein (LDL) ki roto i te oxidatively whakarerekē iti-kiato lipoprotein (ox-LDL) , a ka taea hoki te whakaiti i te whakaaturanga o te CD 36 pūmua i runga i te mata o THP -1 macrophages, ka aukati i nga pūtau ki te tango i te ox-LDL, na reira ka aukati i te tupu o te atherosclerosis.

Ko te mate huka he mate endocrine me te mate metabolic e tino whakararu ana i te hauora o te tangata, a kei te piki haere te mate i runga i te reiti karekau i rite. Kua whakaatuhia e nga rangahau ko te kaempferol he agonist me te rosiglitazone raau taero hypoglycemic, engari he ngoikore rawa atu ona tauhohenga kino i te rosiglitazone. Ka taea e ia te whakanui ake i te urupare o nga pūtau 3T3-L1 ki te huka me te kore e pa ki te lipogenesis. Ko te tangohanga e tohu ana ka noho hei reanga hou mo te taiakitanga insulin

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